Breast cancer is the most common malignant disease and leading cause of cancer-related death for women worldwide. The goals of applying systemic hormone therapy in patients with breast cancers are different in separate disease stages and generally hormone therapy can be given to patients with early disease prior to surgery i. Even though these agents are all functioned in interfering with the hormone-dependent cell survival-signaling pathways in breast cancer cells, their mechanisms of action are completely different Figure 1.
Skip to Content. Use the menu to see other pages. This section explains the types of treatments that are the standard of care for early-stage and locally advanced breast cancer.
Hormone receptor tests are both prognostic and predictive. Hormone receptors also provide information about treatment options. Hormone therapies slow or stop cancer's growth by changing the hormonal milieu.
Barrios, C. Sampaio, J. Vinholes, R.
Human epidermal growth factor receptor 2 HER2 status, along with other factors, such as a tumor's hormone status, helps determine the prognosis and treatment options for breast cancer. There are a few differences between HER2 positive and HER2 negative breast cancers—including the tumor's risk factors, its biology, and its anticipated aggressiveness. Understanding these differences is helpful if you have learned that you have a positive HER2 status.
This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. Learn how to read a research table.
Hormone therapy for breast cancer is a treatment for breast cancers that are sensitive to hormones. The most common forms of hormone therapy for breast cancer work by blocking hormones from attaching to receptors on cancer cells or by decreasing the body's production of hormones. Hormone therapy is only used for breast cancers that are found to have receptors for the naturally occurring hormones estrogen or progesterone. Hormone therapy for breast cancer is often used after surgery to reduce the risk that the cancer will return.